AMIC® Knee

An innovative biological cartilage repair method for treating chondral and osteochondral defects in the knee

  • A minimally invasive, one-step surgical technique
  • Based on microfracturing, the established first-line treatment
  • Natural protection of the super clot resulting from Chondro-Gide®’s unique bilayer structure
  • Positive influence on chondrogenic cell differentiation through Chondro-Gide®
  • Particularly suitable for treating osteochondral and retropatellar defects
  • Verified improvement of clinical function and patient satisfactiont.
  • Straightforward, cost-efficient surgical technique
  • Over 7 years clinical experience.


  1. Benthien JP, Behrens P. Autologous Matrix-Induced Chondrogenesis (AMIC): Combining Microfracturing and a Collagen I/III Matrix for Articular Cartilage Resurfacing Cartilage, 2010, I(I) 65-68
  2. Steinwachs MR, Guggi T, Kreuz PC. Marrow stimulation techniques. Injury. 2008 Apr;39 Suppl 1:S26-31.
  3. Neumann K, Dehne T, Endres M, Erggelet C, Kaps C, Ringe J, Sittinger M. Chondrogenic differentiation capacity of human mesenchymal progenitor cells derived from subchondral cortico-spongious bone. J Orthop Res. 2008 Nov;26(11):1449-56.
  4. Kramer J, Böhrnsen F, Lindner U, Behrens P, Schlenke P, Rohwedel J. In vivo matrix-guided human mesenchymal stem cells. Cellular and Molecular Life Sciences (CMLS) 2006;63:616-626.
  5. Steadman JR, Rodkey WG, Briggs KK. Microfracture to treat full-thickness chondral defects: surgical technique, rehabilitation and outcomes. J Knee Surg. 2002 15(3):170−176. Rohner, D. et al. (2013). Int J Oral Maxillofac Surg. 42(5): 585-91.


Dr. Sanja Saftic
International Product Manager