We use cookies to give you the best experience possible with our website and to improve our communication with you. We consider your selection and will only use the data you have approved us to gather.

These cookies help making a website usable by enabling basic functions like page navigation and access to secure areas of the website. The website cannot function properly without these cookies.

These cookies help website owners to understand how visitors interact with websites by collecting and reporting information anonymously. With this information we can constantly improve the experience we offer on our website.

These cookies are used to track visitors across websites. The intention is to display ads that are relevant and engaging for the individual user and thereby more valuable for publishers and third party advertisers.

Cartilage regeneration

Cartilage and cartilage defects

Cartilage is the tissue that separates bone surfaces. Articular cartilage, which is found in the joints, has a unique composition and structure. Its characteristics allow it to absorb high pressure and sliding forces and to transmit these to the bones. It is also a perfect sliding, selflubricating surface, which permits a mutual gliding and turning of the bones.

Injuries of the joints and the articular cartilage can suddenly arise during sports, exercise and accidents. Because cartilage is avascular and the cartilage cells themselves have a low regenerative capacity, healing of this tissue is difficult to achieve. Over time untreated defects become larger and due to irregularities in the defect edges, adjacent cartilage also becomes damaged.

This leads to severe pain and reduced mobility, with the only treatment for the problem at this stage being an artificial knee. It is therefore important that symptomatic cartilage defects are treated at the earliest possible time to prevent, or at least postpone the requirement for an artificial knee.

Cartilage does not possess the ability to regenerate by itself. For the renewal of damaged articular cartilage, the methods that have proven effective are Microfracturing, Autologous Chondrocyte Implantation (ACI) and Autologous Matrix-Induced Chondrogenesis (AMIC).


Dr. Sanja Saftic
International Product Manager