Frequently Asked Questions (FAQ)

Blood from the defect may be used for mixing. Care should be taken to avoid contamination with salivary bacteria.

Geistlich Bio-Oss® is made from the mineral part of bovine bone. The strictly controlled manufacturing process ensures high quality and safety standards by:

• defined origin of the raw material
• country of origin: Australia (and for some countries also New Zealand) which is historically and currently free of BSE
• selected and certified slaughterhouses
• pre- and post-mortem health inspection for each individual animal
• extremity bone (according to WHO Guideline on tissue infectivity classified as tissues with no detected infectivity or infectious prions)
• effective inactivation methods with 15h treatment at high temperature and cleaning with strong alkaline solutins
• sterilization, double sterile packaging
• official controls by international authorities

The use of local antibiotics is generally unnecessary when utilizing Geistlich Bio-Oss®.

No, if Geistlich Bio-Oss® is autoclaved, moisture can collect in the particles due to the high porosity of the product, which can change the hydrophilic properties. Moreover, Geistlich Bio-Oss® is not approved for re-sterilization in dental practice. Geistlich does not recommend re-sterilization under any circumstances.

A membrane should be used as a barrier against ingrowth of soft tissue¹. Native collagen membranes such as Geistlich Bio-Gide® also support wound healing and increase therapeutic safety in the event of a postoperative wound dehiscence^2,3. Physicians should read the package insert prior to use.

References:

1. Gielkens PF, et al.: Clin Oral Implants Res 2008; 19 : 516-21.
2. Tal H, et al.: Clin Oral Implants Res 2008; 19: 295-302.
3. Becker J, et al.: Clin Oral Implants Res 2009; 20(7): 742-49.

Fundamentally, the use of small particles is recommended for small defects (up to 2 dental alveoli) and for augmenting autogenous grafts, and the large particles for large defects (> 2 dental alveoli, sinus lifts). However, preferences can vary from dentist to dentist.

No.

Use a new Geistlich Bio-Oss Pen®.

Geistlich Bio-Oss Pen® is not approved for re-sterilization.

No.

Depending on the size of the defect between 1.5 to 4 cc of Geistlich Bio-Oss® granules are needed, or 3cc in average. This is equivalent to two 1.5cc Geistlich Bio-Oss Pen® with large granules or three 1cc Geistlich Bio-Oss Pen® with small granules.

0.5 cc Geistlich Bio-Oss Pen®: ~0.5 ml
1.0 cc Geistlich Bio-Oss Pen®: ~1.0 ml
1.5 cc Geistlich Bio-Oss Pen®: ~1.5 ml

A membrane should be used as a barrier against ingrowth of soft tissue¹. Native collagen membranes such as Geistlich Bio-Gide also support wound healing and increase therapeutic safety in the event of a postoperative wound dehiscence^2,3. Physicians should read the package insert prior to use.

References:

1. Gielkens PF, et al.: Clin Oral Implants Res 2008; 19: 516-21.
2. Tal H, et al.: Clin Oral Implants Res 2008; 19: 295-302.
3. Becker J, et al.: Clin Oral Implants Res 2009; 20(7): 742-49.

Fundamentally, the use of small particles is recommended for small defects (up to 2 dental alveoli) and for augmenting autogenous grafts, and the large particles for large defects (> 2 dental alveoli, sinus lifts). However, preferences can vary from dentist to dentist.

Geistlich Bio-Oss® and Geistlich Bio-Oss® Collagen share the same indications. These products may be used interchangeably, as preferred.

Geistlich Bio-Oss® Collagen is recommended for reconstruction of bone defects in maxillofacial surgery and in dental surgery, e.g.:

• Augmentation/reconstruction of alveolar ridges.
• Filling of extraction sockets.
• Implantology: preparation of implant sites, filling of bone dehiscences, and sinus floor augmentations.
• Periodontology: filling of bone defects, support of the membrane during guided bone regeneration (GBR) and guided tissue regeneration (GTR).

The collagen in Geistlich Bio-Oss® Collagen does not function as a membrane. When the socket is not intact, it is recommended to use a membrane to receive optimal results¹.

References:

1. Perelmann-Karmon, et al.:  Int J Periodontics Restorative Dent 2012; 32(4): 459-65.

No. Geistlich Bio-Oss® Collagen is a mixture of 90% Geistlich Bio-Oss® spongiosa granules and 10% highly purified porcine collagen in a block form. Geistlich Bio-Oss® is a natural bone mineral of bovine origin. The collagen facilitates adaptation of the Geistlich Bio-Oss® to the defect site.

No.

Since Geistlich Bio-Oss® Collagen and Geistlich Bio-Gide® are made of collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.

Geistlich Combi-Kit Collagen is packed in a double blister. After the outer blister has been opened sterility can no longer be guaranteed. The product Geistlich Combi-Kit Collagen is registered for one time use only. It is not recommended to use the products separately.

Geistlich Combi-Kit Collagen is recommended for the reconstruction of the alveolar ridge, extraction socket management and augmentation of bone dehiscences.

Since Geistlich Bio-Gide® Perio adheres very well to the defect, it is normally not necessary to utilize fixation screws or pins. However, fixation is possible.

Since Geistlich Bio-Gide® adheres very well to the defect, it is normally not necessary to utilize fixation screws or pins. However, fixation is possible.

The collagen in Geistlich Bio-Oss® Collagen does not function as a membrane. In guided bone regeneration (GBR) procedures a membrane is indicated to obtain optimal results.¹

References:

1. Perelman-Karmon M, et al.: Int J Periodontics Restorative Dent 2013, 32(4): 459-65.

Perio-System Combi-Pack is packed in a double blister. After the outer blister has been opened, product sterility can no longer be guaranteed. The product Perio-System Combi-Pack is registered for single use only.

Geistlich Bio-Gide® is a membrane with a unique bilayer structure. It combines optimal bone formation with complication –free wound healing and predictable outcomes. An exceptional number of scientific publications and proven long-term success underline the unparalleled performance of Geistlich Bio-Gide®.

No, autoclaving or hot-air sterilization irreversibly destroys the collagen structure. The physical properties of the membrane are changed and the consistency of the product becomes like parchment paper. The membrane may not be used. In this case, Geistlich as the manufacturer, cannot accept product liability because the product is not approved for re-sterilization.

The compact layer of Geistlich Bio-Gide® exhibits higher cell occlusiveness than the rough, porous layer. If the membrane is applied side-inverted, integration of the bone cells may take place rather more slowly. However, it is not necessary to remove the membrane.

Since Geistlich Bio-Gide® is made of collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.

Inflammation is a possible complication, which may occur with any surgery. However, biocompatibility of Geistlich Bio-Gide® has been verified by testing.

Geistlich Bio-Gide® is a membrane with a unique bilayer structure. It combines optimal bone formation with complication-free wound healing  and predictable outcomes. The native collagen of Geistlich Bio-Gide® leads to significantly less dehiscence compared to artificially cross-linked membranes.⁴ An exceptional number of scientific publications and proven long-term success underline the unparalleled performance of Geistlich Bio-Gide®.

References:

1. Tal H, et al.: Clin Oral Impl Res 2008; 19: 295-302.

Expert oral surgeons have estimated that a membrane used in Guided Bone Regeneration should maintain its barrier function until the provisional matrix and woven bone are present. Barrier duration is considered to be necessary for 7 to 14 days, in most cases. Optimal barrier function now means that occlusiveness is maintained until the wound heals – a process which normally takes about 2 weeks.
Geistlich Bio-Gide® has proven to support bone regeneration on an equivalent level as membranes with a longer barrier function, with the additional benefit of complication-free wound healing.^1-3

References:

1. Tal H, et al.: Clin Oral Impl Res 2008; 19: 295-302.
2. Becker J, et al.: Clin Oral Impl Res 2009; 20(7): 742-49.
3. Schwarz F, et al.: Clin Oral Impl Res 2008; 19(4): 402-15.

Alveolar bone best regenerates with a membrane designed for Guided bone regeneration. The use of a membrane leads to more and better bone compared to procedures that do not include a membrane.¹

References:

1. Schwarz F, et al.: Clin Oral Impl Res 2008; 19(4): 402-15.

Since Geistlich Bio-Oss® Collagen contains collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.

No, autoclaving or hot-air sterilization irreversibly destroys the collagen structure. The physical properties of the membrane are changed and the consistency of the product becomes like parchment paper. The membrane may not be used. In this case, Geistlich as the manufacturer, cannot accept product liability because the product is not approved for re-sterilization.

The compact layer of Geistlich Bio-Gide® Perio exhibits higher cell occlusiveness than the rough, porous layer. If the membrane is applied side-inverted, integration of the bone cells may take place rather more slowly. However, it is not necessary to remove the membrane.

Since Geistlich Bio-Gide® Perio is made of collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.

Inflammation is a possible complication, which may occur with any surgery. However, biocompatibility of Geistlich Bio-Gide® Perio has been verified by testing.

The surface of Geistlich Bio-Gide® Perio has been made firmer when dry to facilitate periodontal applications. Second, the outer blister pack of Geistlich Bio-Gide® Perio includes four sterile water repellent templates. These can be placed repeatedly in the region of the defect to allow customization of the template before cutting the membrane to the precise shape.

Geistlich Bio-Gide® can heal submerged or open¹ depending on the surgeons preference. The advantages of the secondary intention healing of Geistlich Bio-Gide® are the flapless surgery and the preservation of the mucogingival line.

References:

1. Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2012, 32(4): 421-30.

Geistlich Bio-Gide® Shape and Geistlich Bio-Oss® Collagen can be used in combination for the treatment of extraction sockets with non-intact buccal bone walls.

The use of Geistlich Mucograft® Seal and Geistlich Bio-Oss® Collagen is recommended in extraction sockets with intact buccal bone walls.¹

Reference:

1. Geistlich Mucograft Seal Advisory Board Meeting Report, 2013. Data on file, Geistlich Pharma AG, Wolhusen, Switzerland.

 

Fixation of the membrane (e.g. mattress suture) on top may be indicated to avoid its displacement due to shear loading or mobilization. 

The membrane should be placed inside the alveolus or outside (between the bone and the soft-tissue). From the convenience point of view, it might be easier to place Geistlich Bio-Gide® Shape inside the alveolus.

The long strap of the Geistlich Bio-Gide® Shape should be placed to cover the bony defect of the socket, if present. Thereby the dense surface should face towards the soft tissue, and the rough side should face the defect.

Place the membrane without pre-wetting within the extraction socket. The long strap of the Geistlich Bio-Gide® Shape should be placed to cover the bony defect of the socket, if present. Thereby the dense surface should face towards the soft tissue, and the rough side should face the defect.

To close the extraction socket, both lateral wings of the Geistlich Bio-Gide® Shape membrane should be tucked underneath the mucosa, located mesially and distally of the socket. The upper wing should be tucked  lingually / pallatinally in-between the soft tissue and bone wall.

 

In general, Geistlich Bio-Gide® Shape is based on the Geistlich Bio-Gide® Perio technology to facilitate application comfort. For easier handling, the membrane is pre-cut to a shape that fits for extraction sockets. This also reduces your preparation time.

It depends on the indication:
1. Gain of Keratinised Tissue: Open healing is recommended when Geistlich Mucograft® is used to increase width of keratinised tissue. The innovative design of Geistlich Mucograft® allows excellent healing in open healing situations¹.
2. Recession Coverage: Geistlich Mucograft® should remain completely submerged under the flap to avoid premature resorption of the collagen.^2-4 Direct blood supply is important.

References:

1. Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76.
2. McGuire MK & Scheyer ET: J Periodontol 2010; 81(8): 1108-17.
3. Cardaropoli D, et al.: J Periodontol 2012; 83(3): 321-28.
4. Rotundo R & Pini-Prato G: Int J Periodontics Restorative Dent 2012; 32(4): 413-19.

It depends on the indication:
1. Gain of keratinised tissue: Geistlich Mucograft® should be applied on a periosteal bed^1,2 since blood supply is important. In open healing, the blood is supplied through the edges of the device from the surrounding tissue and from the periosteum.
2. Recession Coverage: Geistlich Mucograft® can be used partially or completely over bone.^3-5 Blood is supplied through the edges of the device  from the surrounding tissue and from the flap covering completely the matrix.

References:

1. Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76.
2. Lorenzo R, et al.: Clin Oral Impl Res 2012; 23(3): 316-24.
3. McGuire MK & Scheyer ET : J Periodontol 2010; 81(8): 1108-17.
4. Cardaropoli D, et al.: J Periodontol 2012; 83(3): 321-28.
5. Rotundo R & Pini-Prato G: Int J Periodontics Restorative Dent 2012; 32(4): 413-19.

In the majority of the individual cases treated thus far and for all the studies performed with Geistlich Mucograft®, one matrix layer was used. Presently, clinical data is not available to prove that several layers of the device outperform a single layer of Geistlich Mucograft®.

The compact structure should face outward, away from underlying bone, with the spongeous structure facing the bone or soft-tissue wound bed. Neither clinical nor comparative data on inverted device performance is available for Geistlich Mucograft®.

Published data show different suturing techniques with Geistlich Mucograft®: non-resorbable^1,2 and resorbable³, 0-5^1,2 and 0-6⁴. There is no clinical evidence showing a benefit of one type of suture over another one, when suturing Geistlich Mucograft®.

References:

1. Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76.
2. Herford AS, et al.: J Oral Maxillofac Surg 2010; 68(7): 1463-70.
3. Cardaropoli D, et al.: J Periodontol 2012; 83(3): 321-28.
4. McGuire MK & Scheyer ET : J Periodontol 2010; 81(8): 1108-17.

No. Geistlich Mucograft^® shows a limited elongation and should always be sutured tension-free.

Our measurements indicate that the matrix does not swell further after hydration (90 minute period examined)¹.

References:

1. Data on file, Geistlich Pharma AG, Wolhusen, Switzerland

Geistlich recommends dry handling and application: Easy to trim, easy to pre-suture.

Geistlich Mucograft® is ready to be applied to the defect and does not need pretreatment or moisture before application. Due to its excellent hydrophilicity, the matrix will hydrate quickly after implantation in the defect by soaking rapidly the patient’s blood.

For both. Geistlich Mucograft® is an alternative to free gingival graft or connective tissue graft for gaining keratinised tissue^1-3. Geistlich Mucograft® is an alternative to CTG for recession coverage^4-6.

References:

1. Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76.
2. Lorenzo R, et al.: Clin. Oral Impl. Res 2012; 23(3): 316-24.
3. Nevins M, et al.: Int J Periodontics Restorative Dent 2011; 31(4): 367-73.
4. McGuire MK & Scheyer ET : J Periodontol 2010; 81(8): 1108-17.
5. Cardaropoli D, et al.: J Periodontol 2012; 83(3): 321-28.
6. Rotundo R & Pini-Prato G: Int J Periodontics Restorative Dent 2012; 32(4): 413-19.

The collagen of Geistlich Mucograft® will be replaced by newly formed soft tissue. The matrix is rapidly vascularised and colonised by soft-tissue cells. This leads to a good integration of the matrix without any signs of foreign body reaction^1,2.

References:

1. Rocchietta I, et al.: Int J Periodontics Restorative Dent 2012; 32(1): e34-40.
2. Ghanaati S, et al.: Biomed Mater 2011; 6(1): 015010.

Geistlich Mucograft® consists of porcine collagen and is specifically designed for soft-tissue regeneration. The matrix is built up of a compact structure that gives stability while allowing open healing, and a spongy structure that supports blood clot stabilisation and ingrowth of soft-tissue cells.

Geistlich Mucograft® is a unique 3D-collagen matrix designed specifically for soft-tissue regeneration as an alternative for autogenous soft-tissue grafts.

Since Geistlich Bio-Gide® Perio and Geistlich Bio-Oss® Collagen are made of collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.

No. Geistlich Mucograft® Seal shows a limited elongation and should always be sutured tension-free.

The compact structure should face outward, away from underlying bone, with the spongeous structure facing the bone or soft-tissue wound bed. Geistlich Mucograft® Seal spongeous structure is striped for easier differentiation of the two sides. The striped spongeous structure should face the bone.

Our measurements indicate that the matrix does not swell further after hydration (90 minute period examined)¹.

References:

1. Data on file, Geistlich Pharma AG, Wolhusen, Switzerland

Geistlich recommends dry handling and application: Easy to trim, easy to pre-suture.

Geistlich Mucograft® Seal  is ready to be applied to seal the socket and does not need pretreatment or moisture before application. Due to its excellent hydrophilicity, the matrix will hydrate quickly after implantation in the defect by soaking rapidly the patient’s blood.

The collagen of Geistlich Mucograft® will be replaced by newly formed soft tissue. The matrix is rapidly vascularised and colonised by soft-tissue cells^1,2. This leads to a good integration of the matrix without any signs of foreign body reaction^3,4.

References:

1. Rocchietta I, et al.: Int J Periodontics Restorative Dent 2012; 32(1): e34-40.
2. Ghanaati S, et al.: Biomed Mater 2011 Feb; 6(1): 015010.
3. Nevins M, et al.: Int J Periodontics Restorative Dent 2011; 31(4): 367-73.
4. Camelo M, et al.: Int J Periodontics Restorative Dent 2012; 32(2): 167-73.

Geistlich Mucograft® Seal consists of porcine collagen and is specifically designed for soft-tissue regeneration. The matrix is built up of a compact structure that gives stability while allowing open healing, and a spongy structure that supports blood clot stabilisation and ingrowth of soft-tissue cells.

Geistlich Mucograft® Seal is a unique 3D-matrix designed specifically for soft-tissue regeneration in extraction sockets for ridge preservation.

Geistlich Mucograft® Seal needs the support of Geistlich Bio-Oss® Collagen underneath for a good ridge preservation of the soft and the hard tissues. After 8 weeks, the soft tissues are healed but the mixture of the blood clot, Geistlich Bio-Oss® Collagen and the newly forming bone is still soft. Nevertheless the implant can be drilled carefully into the socket and the remaining Geistlich Bio-Oss® Collagen will favour the volume preservation of the ridge.

The hydrophile properties of Geistlich Mucograft® Seal favour a rapid moistening of the device either with saline or with blood.

The resorption time of every biomaterial including Geistlich Mucograft® Seal depends on multiple factors: defect size, metabolism and general health of the patient, etc. On the other hand, to determine an average resorption time of Geistlich Mucograft® Seal in humans, biopsies would be needed of the healing soft tissues after tooth extraction at different time points. This procedure is obviously not ethical and thus the average resorption time cannot be measured. However, single histologies indicate that after 8 weeks Geistlich Mucograft® is completely integrated into the newly formed soft tissue. 

Geistlich Mucograft® Seal is specifically designed for soft-tissue regeneration1. The collagen of Geistlich Mucograft® is specially processed to favour immediate blood clot stabilisation. This leads to early vascularisation^1,3, facilitates soft-tissue cell ingrowth²  and excellent integration of the 3D-matrix with surrounding tissues^2,3.  In contrast to other collagen products in the market, Geistlich Mucograft® and Geistlich Mucograft® Seal are well scientifically documented and their clinical benefits are proven.

References:

1. Biocompatibility according to ISO 10993-12001. Data on file Geistlich PharmaAG, Wolhusen, Switzerland.
2. Ghanaati S, et al.:  Biomed Mater 2011; 6(1): 015010.
3. Roccietta I, et al.: Int J Periodontics Restorative Dent 2012; 32(1): e34-40.

After treatment with Geistlich Mucograft®, please follow the same postsurgical management that is usually applied with connective tissue grafts or free gingival grafts.

Yes, in general this product can be applied by any oral healthcare professional. However, local regulations should always be checked.

Production using fermentation, non-animal origin. The hyaluronic acid is not cross-linked.

In Israel, exclusively for the company Prudentix Ltd., which is a direct partner of Geistlich.

Storage at room temperature only: +15 °C to +25 °C guarantees product quality over the shelf life duration of 3 years. For a short term (maximum of 7 days), the product can be stored at +4 °C to +40 °C.

If the product has turned to gel prior to application, e.g. due to warm room temperature, it can be placed in a refrigerator at ≥ +4 °C for approx. two minutes until it becomes liquid again.

There have not yet been any clinical studies conducted with Pocket-X® Gel in peri-implantitis. Therefore, this indication is currently off-label.

Geistlich Mucograft® Seal needs the support of Geistlich Bio-Oss® Collagen underneath for a good ridge preservation of the soft and the hard tissues. After 8 weeks, the soft tissues are healed but the mixture of the blood clot, Geistlich Bio-Oss® Collagen and the newly forming bone is still soft. Nevertheless the implant can be drilled carefully into the socket and the remaining Geistlich Bio-Oss® Collagen will favour the volume preservation of the ridge.

• Type 1: simultaneous to extraction (immediate)
• Type 2: 4-8 weeks after extraction (early implantation)
• Type 3: 12-16 weeks after extraction (delayed implantation)
• Type 4: more than 16 weeks after extraction (late implantation)¹

References:

1. Chen S, Buser D: ITI Treatment Guide Vol 3.

It is contraindicated to use Geistlich Bio-Oss® and Geistlich Bio-Oss® Collagen in case of infected sites (see package insert).

After 4-6 months the socket will be regenerated with hard tissue.¹

References:
1. Cardaropoli D, et al.: Int J Periodont Rest Dent 2012; 32(4) : 421-430

Regardless of the therapy approach, the bundle bone resorbs following tooth loss or extraction. The bundle bone cannot be regenerated, however Geistlich Bio-Oss® or Geistlich Bio-Oss® Collagen effectively substitutes its function in supporting soft-tissue and compensating for buccal bone loss.^1,2

References:

1. Araujo M, et al.: Int J Periodont Rest Dent 2008; 28:123-135.
2. Fickl S, et al.: Journal Clin Periodontol 2008; 35:356-363.

It is a tooth-related structure that resorbs after tooth extraction. The buccal bone wall of the socket is very thin^1-3 and consists largely of the bundle bone.

References:

1. Huynh-Ba G, et al.: Clin Oral Implants Res 2010; 21: 37-42.
2. Januario AL, et al.: Clin Oral Implants Res 2011; 22(10): 1168-71.
3. Araujo MG, Lindhe J: Journal Clin Periodontol 2005; 32: 212-18.

Geistlich Bio-Gide® can be healed submerged or open¹ depending on the surgeons preference. The advantages of the secondary intention healing of Geistlich Bio-Gide® are the flapless surgery and the preservation of the mucogingival line.

References:

1. Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2012; 32(4) :421-30.

Both Geistlich Bio-Oss® OR Geistlich Bio-Oss® Collagen AND Geistlich Bio-Gide® are recommended for bone regeneration in the management of extraction sockets with defect bone walls. When Geistlich Bio-Oss® and Geistlich Bio-Gide® are used in combination, more bone is obtained compared to extraction site using only a bone substitute material¹.
 
The use of Geistlich Mucograft® Seal and Geistlich Bio-Oss® Collagen is recommended in extraction sockets with preserved buccal bone walls².

References:

1. Perelman-Karmon M, et al.: Int J Periodontics Restorative Dent 2012; 32(4): 459-65.
2. Geistlich Mucograft Seal Advisory Board Meeting Report, 2013. Data on file, Geistlich Pharma AG, Wolhusen, Switzerland.

Geistlich Mucograft® Seal should be sutured using non-resorbable sutures, not glued¹. The close adaptation of the device to tissue borders can be accomplished by single interrupted sutures, double interrupted sutures, cross sutures, or sling sutures¹.
The finest possible suture material comfortably used by the surgeon should be selected: for single interrupted sutures, the 6.0 or 5.0 suture size is recommended; for cross-suturing, a 5.0 suture size is appropriate¹.

References:

1. Geistlich Mucograft Seal Advisory Board Meeting Report, 2013. Data on file Geistlich Pharma AG, Wolhusen, Switzerland.

Yes. Geistlich Mucograft® Seal is an alternative to autogenous soft-tissue graft for soft-tissue regeneration. Geistlich Mucograft® Seal does not require pre-hydration or washing. It should be handled and applied in a dry state. Before applying Geistlich Mucograft® Seal, adjacent soft-tissue margins should be de-epithelialized. This allows epithelial cells to freely migrate from the soft-tissue borders into the matrix.

The first impression counts! In order for us to receive the most detailed picture possible of your qualifications and interests, your particulars should be carefully compiled and be comprehensive. Please send your application to Geistlich UK. Your data are thus passed directly to the HR responsible. This way we can speed up the application procedure. 

Your application should contain a covering letter and your CV, as well as references and diplomas. For an application by email you can enclose these as attachments.

Your application is stored by us in our recruitment database. The data contained in your profile is treated confidentially and is used exclusively for the purpose of your application. Your data is only stored by us for as long as you are in the application process. When the recruiting process is completed without subsequent employment, your data will be deleted.

For a decision on selection we would like to have a comprehensive impression of your capabilities, qualifications and your personality.

Initial interview:
After carefully checking your application documents and a positive initial interview, you will be invited to attend a further assessment. The focus will be on you as a person; individual sections of your CV and specialist questions. We would like to know why you are interested in the position and how you match the culture at Geistlich UK.

Second assessment interview:
In a second assessment interview we would like to know more about your specialist knowledge. We may also like to introduce you to other team members.
Use the interview process as an opportunity, ask us questions.

Bone loss can have many different causes – e. g. accidents, or inflammation of the gums and bone due to bacterial tooth plaque (periodontitis). Also after teeth have been removed the height and thickness of the jaw bone diminishes due to the lack of mechanical loading.

Geistlich Bio-Oss® is intermingled with new bone after four to six months and is then included in the natural remodelling process of the bone. The protective Geistlich Bio-Gide® membrane as well as our soft-tissue matrices Geistlich Mucograft® and Geistlich Fibro-Gide® are broken down naturally by the body and replaced by body tissue

Geistlich biomaterials have been part of the standard therapy in the field of bone reconstruction by dentists and dental surgeons for many years. They are the biomaterials most frequently used in regenerative dental medicine throughout the world and have been used many million times, so extensive amounts of data and reports of experience exist. In addition, a great number of clinical studies document the reliability of our products.

The bone recedes in the weeks and months after tooth removal. This might cause some of the following problems:

• Aesthetic impairment: The gum follows the receding bone leading to visible blemishes.
• Hygiene problems: If you wear a bridge, the resulting gaps can make it more difficult, or impossible to clean.
• Difficulty with articulation: The change in the mouth affects articulation.
• Expensive and complicated follow-up treatments: The loss of bone has to be compensated later with laborious bone and soft-tissue augmentation.

Meticulous selection of raw materials, together with a strictly controlled manufacturing process, allows Geistlich biomaterials to conform to the highest safety requirements and ensures high tolerability.

Our strict manufacturing criteria:

• Careful selection of raw materials for the manufacture of Geistlich biomaterials, using bone substance or collagen only from monitored establishments.
• Highly effective cleaning process using chemical and physical treatments and long periods of heating (Geistlich Bio-Oss®).
• Monitored production process with regular checks by independent institutions and state authorities.
• Sterilisation of end products.
• Documented quality assurance system.

1. Dental implants: To support and augment the jaw bone when using dental implants, if the existing amount of bone is not sufficient for long-term stable tooth anchoring.
2. Periodontitis: To preserve existing teeth that have lost their secure anchorage in the jaw bone as a result of periodontal disease (e.g. due to bacterial tooth plaque).
3. Extensive bone damage: Bone reconstruction after extensive bone loss.

Biomaterials are non-viable materials that can be implanted to replace or repair missing tissue. They may be of natural origin or synthesised in a laboratory and are able to interact with the human body.

Investigators still cannot agree on the importance of the presence of keratinised tissue. Various studies have shown, however, that lack of keratinised tissue around implants is associated with

• Gingival recession over a period of five years¹
• Soft-tissue attachment loss²
• Increased plaque accumulation lingually¹
• Inflammation of the soft tissue²
• More frequent bleeding¹

References:

1. Schrott AR, et al.: Clin Oral implants Res 2009; 20(10): 1170-17.
2. Chung DMT, et al.: J Periodontol 2006; 77(8): 1410-20.